Souce:Synthesis

Hexapeptide that mimics the activity of FOXO3a (member of the Forkhead box transcription factors), which is involved in cell repair, renewal and longevity. This peptide protects DNA from damage, stimulates its natural repair pathways and reverts senescence in fibroblasts.

DNA protection peptide maintains genomic integrity by protecting and repairing DNA damage induced by several agents, and delays cellular senescence to ensure longer and healthier aging.

The maintenance of DNA integrity is essential for the proper functioning and survival of organisms. DNA strands suffer from the constant challenge of endogenous and exogenous genotoxic agents as well as replication errors.

UV-induced lesions may result in the formation of cyclobutane pyrimidine dimers (CPDs), a well-known form of pyrimidine dimers. Such damage can distort the structure of the DNA, altering its transcription and replication. Checkpoint pathways monitor DNA structure and control cell-cycle arrest allowing for repair and continue progression if every- thing is correct, before a mistake can be propagated to daughter cells.

FOXO3a acts as a master regulator that determines cell fate once damage is detected. Depending on the severity of the damage, this key transcription factor forces a state of quiescence in cells signaling for repair of errors or apoptosis. The active form of FOXO3a increases the level of well known anti- oxidants, induces the expression of genes involved in DNA-damage repair and triggers cell death when necessary.

DNA protection peptide imitates the activity of FOXO3a, increasing the expression of several genes involved in DNA repair pathways. It also provides protection to cells and rejuvenates fibroblasts, retarding their senescence.